Authored by Dr. David Alter
In the movie musical My Fair Lady made famous by Audrey Hepburn, she sings a song whose words begin, “The Rain in Spain Falls Mainly in the Plain.” Her song signals her growing ability to achieve her full but untapped potential. Every day, millions of people struggle to overcome the limitations imposed by their personal histories. These are individuals who face the misery and despair that all too often arises with chronic pain.
Chronic pain has bedeviled healers for thousands of years. Invisible, untouchable, and yet so many are touched by it – more than 70 million Americans per year! A key aspect of chronic pain that makes its successful management so challenging is its disconnection from obvious tissue injury. Typically, as the physical body heals, the process of healing turns off the nerve signals that generated the pain sensations in response to the original injury.
What is difficult to understand is that over time pain signals become disconnected from actual tissue damage. This involves a modification to the body’s pain signaling process. Pain is an experience that is encoded in the brain in through state dependent learning experiences. In other words, the experience we call pain is a type of memory that is encoded into the neural circuits of the brain, ready to be reactivated when any of the other elements that were present at the time of the original injury are once again present. For example, when my young adult son was injured playing his favorite sport he needed stitches that were sown into his mouth without sufficient anesthetic. When he began to anticipate going to have the stitches removed, he began to hurt again. The hurt he felt involved reactivation of the state dependent learning that linked together the memory of stitches with the memory of pain. The anticipation of going to have stitches removed reactivated pain! The original emotional state (scared), the physical context (doctor’s office), the sensory cues (white coat, hospital smell, overhead paging, etc.) also served to reactive the pain because they were encoded as part of the original state dependent pain experience.
While this example involves an acute pain experience, you can appreciate the relevance to chronic pain conditions, where the encoded emotional, contextual, sensory, and cognitive cues linked to pain are more common and have been reactivated so much more powerfully over a longer period of time. Still, the implication is clear: As hard as it is to accept, the fact of the matter is that chronic pain really is “in your head!” It is wired into the brain’s network of nerves, ready to “fire” in response to so many different triggers.
That the pain is in the head makes it no less real! In fact, it allows a whole new approach to managing it: learning ways to re-program pain program wired into the brain. To return to our theme, the key to management of chronic pain involves learning to change the “remembered pain,” the memory pattern that gets established in the brain and which is responsible for the activation, maintenance and exacerbations of chronic pain conditions. If Audrey Hepburn were to star in a pain management movie, perhaps she would sing, “The Pain, its Plain, Stems Mainly from the Brain!”
There are a number of ways to modify chronic pain memories: the pain-maintaining signaling patterns that are at the core of chronic pain conditions. In the next entry to this blog, six suggestions for modifying pain maintaining memory circuits will be introduced to you. Each of the pattern-modifying techniques is useful precisely because of its proven capacity to alter the ways in which remembered pain signals are generated.


We are made up of several trillion cells that are interconnected with one another. The patterns of interaction among and within these cells are unimaginably complex. And yet, the vast majority of the time, this vast network of interconnected cells hums along in ways that allow you to smoothly carry out the activities of your daily life. Cells actively regulate their boundary (i.e., the cellular membrane) with the world around them by asking four basic questions that you can learn to apply to yourself as you regulate your relationship to yourself and to the world around you.
At first, the symptom pattern of chronic pain may seem unrelated to a pattern involving gut dysfunction, (Irritable Bowel Syndrome, for example), but all symptom patterns represent a loss of adaptive flexibility of the mind and body. Adaptive flexibility involves the capacity to adjust to the ever-changing circumstances of your life while maintaining a steady sense of balance and control in your life. The greater your ability to adjust and adapt to the circumstances of your life the greater the likelihood that you would describe yourself as healthy. And the more you can learn to increase your adaptive flexibility, the more likely you are to regain or restore your health.
Sounds strange? Think for a few moments about the kinds of suggestions we hear or give ourselves each day and you’ll recognize they are still suggestions about improving our ability to adjust and adapt in ways that are not all that different from what Hippocrates might have advised a patient in Greece 2500 years ago: “I’ve got to stop burning the candle at both ends;” “I should eat less and exercise more;” “I’ve got to stop picking the same type of relationship partner over and over again;” “I have to take some risks if my situation is ever going to change;” “I have to get ‘in touch’ with my feelings;” “I have to give more and expect less;” “I have to over-extend less and take better care of myself.” “I have to live my life with integrity that is consistent with my basic values.” Each statement reflects the recognition that you have gotten stuck in a repeating pattern of functioning that is negatively affecting your health. Repeating unhealthy patterns of living is the primary sign of the loss of adaptive flexibility, and often predicts that a loss of physical, emotional or mental health will soon follow. 